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S. B. Junne ¹, Archana B. Kadam ¹, Archana Y. Vibhute ¹, S. L. Shinde ², R. B. Patil ², Y. B. Vibhute ¹

Affiliations
1 P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-05 (M.S.), IN
2 Department of Botany, Yeshwant Mahavidyalaya, Nanded-05 (M.S.), IN

Abstract

A convenient synthesis of secondary amines has been prepared by the reduction of Schiff bases by using sodium borohydride as a selective reducing agent. The Schiff bases were synthesized from 2-hydroxy-3-iodo-5-phenyl benzaldehyde moiety. The structures of the compounds have been confirmed by elemental analysis and spectral data. The antibacterial activity of these compounds has also been screened.

Keywords

Schiff Bases, Secondary Amines, Sodium Borohydride, Antibacterial Activity.

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V. A. Navale ¹, S. S. Mokle ¹, Archana Y. Vibhute ¹, K. G. Karamunge ¹, S. V. Khansole ¹, S. B. Junne ¹, Y. B. Vibhute ¹

Affiliations
1 P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (M.S.), IN

Abstract

The synthesis of heterocyclic compounds containing flavones (4a-i) and 1,5-benzothiazepines (5a-i) from chalcone derivatives containing 3,4-methylenedioxy phenyl ring using microwave irradiation in 80-97% yield within 2-4 min. The work-up is simple, shorter reaction time, increase in reaction rate with better yields. The structures of synthetic compounds have been characterized using IR and ¹H NMR spectral data together with halogen analysis. All synthesized compounds have been screened for their antibacterial activity.

Keywords

Chalcones, Flavones, 1,5-Benzothiazepines, Microwave Irradiation, Antibacterial Activity.

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